Increased in vitro fitness of multi- and extensively drug-resistant F15/LAM4/KZN strains of Mycobacterium tuberculosis
نویسندگان
چکیده
منابع مشابه
Population structure of multi- and extensively drug-resistant Mycobacterium tuberculosis strains in South Africa.
Genotyping of multidrug-resistant (MDR) Mycobacterium tuberculosis strains isolated from tuberculosis (TB) patients in four South African provinces (Western Cape, Eastern Cape, KwaZulu-Natal, and Gauteng) revealed a distinct population structure of the MDR strains in all four regions, despite the evidence of substantial human migration between these settings. In all analyzed provinces, a negati...
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Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 13, No. 9, September 2007 1429 niazid chemoprophylaxis due to resistance of the infecting organism. Decreased susceptibility to isoniazid among M. kansasii isolates is common (7,8), and this microorganism is naturally resistant to pyrazinamide (9). This pattern of resistance is a serious obstacle for the use of these drugs in monotherapy or ...
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Tuberculosis remains one of the main problem worldwide and the emergence of MDR-M.tuberculosis strains has become a major concern.The decreased activity of first line drugs,especially to isoniazid and rifampin causes some problems in the treatment of MDR-tb. Compared with the other infections,drugs clinically active to M.tuberculosis relatively more fewer (1). Because of this reason alternative...
متن کاملMolecular characterization of multidrug- and extensively drug-resistant Mycobacterium tuberculosis strains in Jiangxi, China.
In this study, a total of 77 multidrug-resistant and extensively drug-resistant (MDR and XDR, respectively) isolates of Mycobacterium tuberculosis were characterized among samples from patients living in Jiangxi province, China. The following two approaches were used: (i) genotyping all drug-resistant isolates by the 15-locus MIRU-VNTR (mycobacterial interspersed repetitive-unit-variable-number...
متن کاملCharacterization of extensively drug-resistant Mycobacterium tuberculosis in Nepal.
The emergence of extensively drug-resistant tuberculosis (XDR-TB) has raised public health concern for global control of TB. Although molecular characterization of drug resistance-associated mutations in multidrug-resistant isolates in Nepal has been made, mutations in XDR isolates and their genotypes have not been reported previously. In this study, we identified and characterized 13 XDR Mycob...
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 2014
ISSN: 1198-743X
DOI: 10.1111/1469-0691.12415